Document Type

Article

Publication Date

4-26-2021

Publication Title

Endocrine connections

ISSN

2049-3614

Department(s)

Department of Medicine; Fellows and Residents

Keywords

Graves’ disease, Hashimoto’s disease, fat tissue, nicotinamide phosphoribosyltransferase, pre-B-cell colony enhancing factor, visfatin

Abstract

Dysregulation of thyroid function has known impact on body metabolism, however, data regarding metabolic outcome after restoration of thyroid function is limited. Therefore, the aim of the study was to investigate the effect of restoration of euthyroidism on serum visfatin, and its associations with insulin resistance and body composition. This is an observational study with consecutive enrollment. Forty-nine hyperthyroid (median age of 34 years) and 44 hypothyroid women (median age of 46 years) completed the study. Laboratory parameters and body composition analysis were assessed before and after the therapy. In the hyperthyroid group, visfatin concentrations increased (P < 0.0001), while glucose concentrations decreased (P < 0.0001). Total body mass and fat mass in the trunk and limbs significantly increased during the treatment. In the hypothyroid group, significant weight loss resulted from decrease of fat and muscle masses in trunk and limbs. Visfatin serum concentrations positively correlated with total fat mass (r = 0.19, P = 0.01) and insulin concentrations (r = 0.17, P = 0.018). In conclusion, restoration of thyroid function is not associated with beneficial changes in body composition, especially among hyperthyroid females.

Volume

10

Issue

4

First Page

462

Last Page

470

DOI

10.1530/EC-21-0059

PubMed ID

33764900

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