Title

Firibastat: A Novel Brain Aminopeptidase Inhibitor - A New Era of Antihypertensive therapy

Document Type

Article

Publication Date

4-3-2021

Publication Title

Current problems in cardiology

E-ISSN

1535-6280

Department(s)

Cardiology Division; Fellows and Residents

Abstract

Global incidence and prevalence of hypertension continues to increase and remains a significant challenge. The ever-increasing number of cases are due to comorbid conditions such as obesity and diabetes, as well as lifestyle indiscretions such as excessive salt intake. Hypertension, congestive heart failure, and kidney disease are all conditions resulting from abnormal Renin-Angiotensin-Aldosterone activation and adverse remodeling. Firibastat, a novel Brain Aminopeptidase inhibitor, may be able to help achieve blood pressure control in those with resistant hypertension. In this review article, we will discuss the biochemical pathway of firibastat and various trials assessing drug efficacy in animals and humans. This drug has the potential to curb the risk of uncontrolled hypertension and help improve long term cardiovascular morbidity and mortality.

First Page

100859

DOI

10.1016/j.cpcardiol.2021.100859

PubMed ID

33994025

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