USF-LVHN SELECT
Discovering dominant tumor immune archetypes in a pan-cancer census.
Publication/Presentation Date
1-6-2022
Abstract
Cancers display significant heterogeneity with respect to tissue of origin, driver mutations, and other features of the surrounding tissue. It is likely that individual tumors engage common patterns of the immune system-here "archetypes"-creating prototypical non-destructive tumor immune microenvironments (TMEs) and modulating tumor-targeting. To discover the dominant immune system archetypes, the University of California, San Francisco (UCSF) Immunoprofiler Initiative (IPI) processed 364 individual tumors across 12 cancer types using standardized protocols. Computational clustering of flow cytometry and transcriptomic data obtained from cell sub-compartments uncovered dominant patterns of immune composition across cancers. These archetypes were profound insofar as they also differentiated tumors based upon unique immune and tumor gene-expression patterns. They also partitioned well-established classifications of tumor biology. The IPI resource provides a template for understanding cancer immunity as a collection of dominant patterns of immune organization and provides a rational path forward to learn how to modulate these to improve therapy.
Volume
185
Issue
1
First Page
184
Last Page
203
ISSN
1097-4172
Published In/Presented At
Combes, A. J., Samad, B., Tsui, J., Chew, N. W., Yan, P., Reeder, G. C., Kushnoor, D., Shen, A., Davidson, B., Barczak, A. J., Adkisson, M., Edwards, A., Naser, M., Barry, K. C., Courau, T., Hammoudi, T., Argüello, R. J., Rao, A. A., Olshen, A. B., Immunoprofiler Consortium, … Krummel, M. F. (2022). Discovering dominant tumor immune archetypes in a pan-cancer census. Cell, 185(1), 184–203.e19. https://doi.org/10.1016/j.cell.2021.12.004
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
34963056
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article