Belatacept during pregnancy in renal transplant recipients: Two case reports.
Publication/Presentation Date
8-1-2018
Abstract
Impaired fertility is common among patients with chronic organ failure, including end-stage renal disease (ESRD). Women of childbearing age undergoing transplantation may experience rapid return of fertility. Pregnancy posttransplant presents numerous risks for the patient, fetus, and allograft. Maternal risks include hypertension and preeclampsia. Allograft risks include acute rejection and failure of the organ, and fetal risks include miscarriage, birth defects from immunosuppressants, premature delivery, and low birth weight. Belatacept, a selective T cell costimulation blocker, was approved for use in kidney transplant recipients in the United States in 2011. Little is known about the safety of belatacept during pregnancy in humans. We describe 2 cases of successful pregnancy and delivery with the use of belatacept-based immunosuppression. The Transplant Pregnancy Registry International (TPR) is a voluntary registry for transplant recipients who have had pregnancies or fathered a pregnancy posttransplant. To date, these 2 cases are the only known exposures to belatacept that have been reported to the TPR.
Volume
18
Issue
8
First Page
2079
Last Page
2082
ISSN
1600-6143
Published In/Presented At
Combs, J., Kagan, A., Boelkins, M., Coscia, L., Moritz, M., & Hofmann, R. M. (2018). Belatacept during pregnancy in renal transplant recipients: Two case reports. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 18(8), 2079–2082. https://doi.org/10.1111/ajt.14911
Disciplines
Nephrology | Obstetrics and Gynecology | Surgery
PubMedID
29719109
Department(s)
Department of Surgery
Document Type
Article