Local ZnCl2 accelerates fracture healing.
This study evaluated the effect of local zinc chloride (ZnCl2 ), an insulin mimetic agent, upon the early and late parameters of fracture healing in rats using a standard femur fracture model. Mechanical testing, radiographic scoring, histomorphometry, qualitative histological scoring, PCNA immunohistochemistry, and local growth factor analysis were performed. Fractures treated with local ZnCl2 possessed significantly increased mechanical properties compared to controls at 4 weeks post fracture. The radiographic scoring analysis showed increased cortical bridging at 4 weeks in the 1.0 (p=0.0015) and 3.0 (p
Published In/Presented At
Wey, A., Cunningham, C., Hreha, J., Breitbart, E., Cottrell, J., Ippolito, J., Clark, D., Lin, H. N., Benevenia, J., O'Connor, J. P., Lin, S. S., & Paglia, D. N. (2014). Local ZnCl2 accelerates fracture healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(6), 834–841. https://doi.org/10.1002/jor.22593
Medicine and Health Sciences
Department of Surgery