Mitral valve infective endocarditis: benefit of early operation and aggressive use of repair.
BACKGROUND: In-hospital mortality rates for left-sided infective endocarditis (IE) exceed 20%. We investigated the outcomes of an aggressive approach to mitral valve IE that emphasizes early surgical intervention and preferential performance of mitral valve repair.
METHODS: We reviewed 89 consecutive operations in 87 patients for native mitral valve IE at a single institution from 2002 to 2007. Operations occurred promptly after completion of preoperative studies. Independent risk factors for death were investigated using multivariable logistic regression.
RESULTS: Mitral valve repair was accomplished in 56 of 89 patients (63%). Perioperative mortality was 4.4% (n = 4). Survival rates at 1 and 5 years were 89.9% (80 of 89) and 82.0% (73 of 90). There was a survival benefit for repair vs replacement at 1 (p = 0.03) and 5 years (p = 0.0017). Repair vs replacement (odds ratio [OR], 0.2; 95% confidence interval [CI], 0.06 to 0.72), diabetes (OR, 4.43; 95% CI, 1.18 to 16.66), and renal failure (OR, 3.65; 95% CI, 1.3 to 12.91) were independent risk factors for late mortality. Among 59 patients with active IE, preoperative head computed tomography (CT) showed 29 (49%) had abnormalities, including 12 (41%) with intracerebral hemorrhage. The median interval was 4 days from admission to operation. The rate of permanent postoperative stroke was 1.1% (1 of 89).
CONCLUSIONS: These results support early surgical therapy for mitral valve IE. Head CT abnormalities do not warrant delay of operation. Mitral valve repair was associated with a long-term survival advantage compared with valve replacement.
Published In/Presented At
Shang, E., Forrest, G. N., Chizmar, T., Chim, J., Brown, J. M., Zhan, M., Zoarski, G. H., Griffith, B. P., & Gammie, J. S. (2009). Mitral valve infective endocarditis: benefit of early operation and aggressive use of repair. The Annals of thoracic surgery, 87(6), 1728–1734. https://doi.org/10.1016/j.athoracsur.2009.02.098
Medicine and Health Sciences
Department of Surgery