Impact of angiotensin system inhibitors on esophageal cancer survival.
INTRODUCTION: Angiotensin system inhibitors are associated with improved prognosis in patients with gastrointestinal and hepatobiliary cancers. Data suggest that renin-angiotensin system signaling stimulates the tumor's immune microenvironment to impact overall survival. The goal of this study is to investigate the role of angiotensin system inhibitor use on the overall survival and disease-free survival of esophageal cancer patients.
METHODS: Retrospective review of esophagectomy patients with esophageal adenocarcinoma and squamous cell cancer at a single institution tertiary care center from 2007 to 2018 was performed. Outcomes include overall survival and disease-free survival. Patient characteristics were compared with
RESULTS: One hundred seventy-one patients were identified and 123 underwent esophagectomy for cancer. No significant differences in patient demographics were found between angiotensin system inhibitor users and non-angiotensin system inhibitor users except for the rates of hypertension (40% vs 94%,
CONCLUSION: Angiotensin system inhibitors have been shown to improve survival and decrease relative risk for several types of cancers; however, our data do not support the same effect on esophageal cancer patients undergoing curative intent surgery. Further research is needed to investigate potential nuances in angiotensin system inhibitor dose, chronicity of use, esophageal pathology, and applicability to nonsurgical candidates.
Published In/Presented At
Wang, X., Sweigert, P., Eguia, E., Varsnik, M. A., Renz, C. R., Terrasse, W. A., Gauthier, M., Aranha, G., Knab, L. M., & Abood, G. (2020). Impact of angiotensin system inhibitors on esophageal cancer survival. Surgery open science, 3, 34–38. https://doi.org/10.1016/j.sopen.2020.08.001
Medicine and Health Sciences
Department of Surgery, Department of Surgery Residents, Fellows and Residents