Laboratory testing and imaging in the evaluation of cranial cerebrospinal fluid leaks and encephaloceles.

Publication/Presentation Date

10-1-2019

Abstract

PURPOSE OF REVIEW: To summarize the current evidence on the diagnostic evaluation of cranial cerebrospinal fluid (CSF) leaks and encephaloceles, including laboratory testing and imaging studies.

RECENT FINDINGS: The most sensitive and specific laboratory tests for CSF leak diagnosis are beta-2-transferrin and beta trace protein assays, the former more commonly used because of availability. Imaging studies used for localization of the leak site include high resolution computed tomography (HRCT) and magnetic resonance cisternography (MRC), often used in combination. Intrathecal contrast administration is reserved for complex cases with prior equivocal test results or for patients with multiple skull base defects to localize the leak site.

SUMMARY: Diagnosis of CSF leaks and encephaloceles is aimed at both confirming the leak and localizing the leak site. Future advancements in testing techniques may shorten the diagnostic process, limit the need for invasive testing, and improve the safety of such testing in indicated cases.

Volume

27

Issue

5

First Page

339

Last Page

343

ISSN

1531-6998

Disciplines

Medicine and Health Sciences

PubMedID

31461732

Department(s)

Department of Surgery, Division of Otolaryngology

Document Type

Article

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