Evidence for Oncolytic Viral Eradication of Cholesteatoma In Vitro.
Cholesteatomas (CHSTs) are congenital or acquired lesions of the temporal bone that are associated with significant morbidity. We hypothesized that an oncolytic herpes simplex virus (oHSV) could preferentially eradicate primary human CHST cells in vitro and that this virus will replicate selectively and efficiently in CHST cells when compared with control cells. In this work, primary human CHST cells were cultured from surgically collected tissue. Cholesteatomas and control cells were grown and infected by oncolytic oHSV. More than 80% CHST cells versus
Published In/Presented At
Samy, R. N., Lipschitz, N., Earl, B. R., & Cripe, T. P. (2019). Evidence for Oncolytic Viral Eradication of Cholesteatoma In Vitro. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 160(5), 891–893. https://doi.org/10.1177/0194599818821863
Medicine and Health Sciences
Department of Surgery