A preliminary study of mechanically stress-induced changes in the extracellular matrix of the canine intervertebral disc.
The intervertebral discs of a young (age, 3 years) and an old (age, 8 years) dog were isolated as motion segments and cyclically stressed in physiologic nondestructive axial compression loads. Chemical analysis of the matrix of the annulus fibrosus revealed a shift in proteoglycan molecular size from larger to smaller moieties for the older dog but not for the younger. These preliminary results may indicate an age-related inability of the disc to tolerate cyclic stress.
Published In/Presented At
Vasan, N. S., Gutteling, E. W., Lee, C. K., Cibischino, M., & Parsons, J. R. (1991). A preliminary study of mechanically stress-induced changes in the extracellular matrix of the canine intervertebral disc. Spine, 16(3), 317–320. https://doi.org/10.1097/00007632-199103000-00010
Medicine and Health Sciences
Department of Surgery