Single center observation of the role of pre-existing HLA-DP antibodies in humoral rejection following renal transplantation.
Publication/Presentation Date
12-1-2018
Abstract
HLA antigens, including HLA-A, B, C, DR and DQ have long been known to have an effect on transplant outcome. Presence of antibodies to these antigens is detrimental to transplant outcome as it ends up to either acute or chronic humoral rejection depending on the titer of the antibodies to these antigens. However, the role of HLA-DP is not fully clear, predominantly due to lack of adequate publications and the fact that DP antigen and antibody detection became possible with the advent of new beads technology. As a results, allocation system has not yet included HA-DP antibodies in virtual crossmatching. This report presents two novel cases with strong HLA-DP antibodies which resulted in acute humoral rejection (AMR).
Volume
51
First Page
58
Last Page
61
ISSN
1878-5492
Published In/Presented At
Nikaein, A., Lerman, M., Rofaiel, G., & Allam, S. R. (2018). Single center observation of the role of pre-existing HLA-DP antibodies in humoral rejection following renal transplantation. Transplant immunology, 51, 58–61. https://doi.org/10.1016/j.trim.2018.09.002
Disciplines
Medicine and Health Sciences
PubMedID
30237092
Department(s)
Department of Surgery
Document Type
Article