Effect of splenectomy on first cadaver kidney transplants.
Publication/Presentation Date
1-1-1980
Abstract
A prospective study was begun in January 1975 to evaluate the effect of splenectomy on graft and patient survival in recipients of first cadaver kidney transplants. Ninety-two cases were evaluated. Splenectomy increased the survival of both grafts and recipients. The benefit from splenectomy compensated readily for the perioperative morbidity of splenectomy and the long-term increased risk of sepsis from certain bacteria for the asplenic patient. Splenectomy exerted its effect by reducing the incidence and intensity of rejection episodes. It was not clear whether the observation resulted from a direct immunosuppressive effect of splenectomy or from the increased tolerance to azathioprine observed in asplenic recipients. Finally, splenectomy negated an effect of race that had been observed earlier for survival of cadaver transplants and recipients.
Volume
192
Issue
4
First Page
553
Last Page
561
ISSN
0003-4932
Published In/Presented At
Stuart, F. P., Reckard, C. R., Ketel, B. L., & Schulak, J. A. (1980). Effect of splenectomy on first cadaver kidney transplants. Annals of surgery, 192(4), 553–561. https://doi.org/10.1097/00000658-198010000-00013
Disciplines
Medicine and Health Sciences
PubMedID
7000012
Department(s)
Department of Surgery
Document Type
Article