Osteosarcoma: improved survival with anticoagulation and amputation.
A study of warfarin anticoagulation as an adjunct to amputation of osteosarcomas was undertaken after finding dramatic results in experimental systems. Anticoagulation was started 7 days preoperatively, continued during the operation, and for up to six months postoperatively. Three of 21 (14%) non-anticoagulated control patients are alive at 5-11 years. Five of 9 (56%) of the anticoagulated patients remain alive 5-8 years. The presumed mechanism of increased survival is an inhibition of fibrin deposition around circulating tumor cells, thereby preventing their adherence to capillary endothelium to initiate metastasis formation.
Published In/Presented At
Hoover, H. C., Jr, Ketcham, A. S., Millar, R. C., & Gralnick, H. R. (1978). Osteosarcoma: improved survival with anticoagulation and amputation. Cancer, 41(6), 2475–2480. https://doi.org/10.1002/1097-0142(197806)41:6<2475::aid-cncr2820410657>3.0.co;2-3
Medicine and Health Sciences
Department of Surgery