Aspirin decreases platelet uptake on Dacron vascular grafts in baboons.
The influence of a single dose of aspirin (5.4-7.4 mg/kg) on platelet uptake on 4-mm Dacron interposition grafts was studied in a baboon model using gamma camera scanning for 111-Indium labeled platelets. In vitro assessment of platelet function after aspirin administration revealed that in the baboon, as in the human, aspirin abolished arachidonic acid-induced platelet aggregation, prolonged the lag time between exposure to collagen and aggregation, and decreased plasma thromboxane B2 levels. Aspirin also prolonged the template bleeding time. Scans for 111-Indium labeled platelets revealed that pretreatment with a single dose of aspirin decreased platelet uptake on 4-mm Dacron carotid interposition grafts. This decrease in platelet uptake was associated with a significant improvement in 2-hour graft patency and with a trend toward improved 2-week patency.
Published In/Presented At
Mackey, W. C., Connolly, R. J., Callow, A. D., Keough, E. M., Ramberg-Laskaris, K., McCullough, J. L., O'Donnell, T. F., Jr, Melaragno, A., Valeri, C. R., & Weiblen, B. (1984). Aspirin decreases platelet uptake on Dacron vascular grafts in baboons. Annals of surgery, 200(1), 93–99. https://doi.org/10.1097/00000658-198407000-00017
Medicine and Health Sciences
Department of Surgery