Factors associated with severe intracranial hypertension in candidates for emergency liver transplantation.
Publication/Presentation Date
5-1-1993
Abstract
Cerebral edema is the leading cause of death in patients with fulminant hepatic failure (FHF). Emergency OLT is often a life-saving therapy for FHF but severe cerebral edema is a contraindication to transplantation. We attempted to identify clinical and biochemical factors associated with the development of severe intracranial hypertension in FHF. Fever, psychomotor agitation, and arterial hypertension were more frequently observed preceding episodes of severe intracranial hypertension, and more than 50% of FHF patients with uncontrolled intracranial hypertension sustained severe brain injury in our series. These observations suggest that vigorous treatment of fever, arterial hypertension, and agitation are important aspects of the intensive care management of FHF patients to maintain their OLT candidacy.
Volume
55
Issue
5
First Page
1071
Last Page
1074
ISSN
0041-1337
Published In/Presented At
Muñoz, S. J., Moritz, M. J., Bell, R., Northrup, B., Martin, P., & Radomski, J. (1993). Factors associated with severe intracranial hypertension in candidates for emergency liver transplantation. Transplantation, 55(5), 1071–1074. https://doi.org/10.1097/00007890-199305000-00025
Disciplines
Medicine and Health Sciences
PubMedID
7684536
Department(s)
Department of Surgery
Document Type
Article