Peritoneal seeding following potentially curative resection of colonic carcinoma: implications for adjuvant therapy.
Publication/Presentation Date
8-1-1991
Abstract
Adjuvant therapeutic strategies for colon cancer are based on the knowledge of tumor recurrence patterns following potentially curative resection. Innovative methods for regional delivery of chemotherapy to the liver and peritoneal surfaces are now available to complement systemic treatment. We reviewed clinical, reoperation, and autopsy series to determine the incidence of peritoneal seeding following colon cancer resection. The data suggest a 25-35 percent peritoneal failure rate among patients that recur, indicating that intraperitoneal chemotherapy is a sensible adjuvant approach. The theory behind intraperitoneal chemotherapy and potential complications is discussed. We suggest initiation of clinical trials combining systemic and intraperitoneal chemotherapy.
Volume
34
Issue
8
First Page
723
Last Page
727
ISSN
0012-3706
Published In/Presented At
Brodsky, J. T., & Cohen, A. M. (1991). Peritoneal seeding following potentially curative resection of colonic carcinoma: implications for adjuvant therapy. Diseases of the colon and rectum, 34(8), 723–727. https://doi.org/10.1007/BF02050360
Disciplines
Medicine and Health Sciences
PubMedID
1855433
Department(s)
Department of Surgery
Document Type
Article