Renin release in turtles: effects of volume depletion and furosemide administration.
Publication/Presentation Date
7-1-1985
Abstract
To gain insight into the phylogenetic history of mechanisms controlling renin release, we conducted studies in the freshwater turtle Pseudemys scripta. Maneuvers known to stimulate renin release in mammals were evoked in the turtle, and the response was compared with that in mammals. Cumulative hemorrhage (30% blood vol) in anesthetized turtles failed to increase renin even though arterial pressure was reduced to 50% of control. An even more severe hemorrhage (60% blood loss) or hypotension induced by nitroprusside infusion in unanesthetized turtles also failed to evoke an enhanced level of renin. However, under identical experimental conditions, a 15% blood loss in rats increased renin at least fourfold (P less than 0.01). In other studies 48 h of furosemide administration in awake turtles increased renin more than threefold (P less than 0.05) and were accompanied by concomitant reductions in plasma sodium and potassium (P less than 0.05). The general conclusions drawn from these studies is that renin secretion in this primitive vertebrate is similar to that in mammals with respect to renal tubular and electrolyte mechanisms, but unlike all mammals tested these turtles do not possess an intrarenal baroreceptor component in renin control.
Volume
249
Issue
1 Pt 2
First Page
100
Last Page
105
ISSN
0002-9513
Published In/Presented At
Cipolle, M. D., & Zehr, J. E. (1985). Renin release in turtles: effects of volume depletion and furosemide administration. The American journal of physiology, 249(1 Pt 2), R100–R105. https://doi.org/10.1152/ajpregu.1985.249.1.R100
Disciplines
Medicine and Health Sciences
PubMedID
3893163
Department(s)
Department of Surgery
Document Type
Article