Validity of current experimental evidence on laparoscopic surgery for colorectal cancer.

Authors

R Bergamaschi

Publication/Presentation Date

1-1-2004

Abstract

Experimental animal studies can provide crucial evidence for the evaluation and refinement of the controversial area of many areas of surgery. Recently, during the surge in interest in laparoscopic surgery, in particular for colorectal cancer, 72 animal studies have been published between 1995 and 2001. However, the question remains as to which of theses data can be suitably extrapolated to the human population. Forty-five of 47 studies, which use cell suspensions, relied on percutaneous intraperitoneal injection of cancer cells to induce peritoneal carcinomatosis. One study described a laparotomy-based model with injection of tumor cells into the cecal lumen while a different study presented the cancer cells via enema. In this study, sigmoid resection was performed before colorectal solid tumor growth.

Volume

51

Issue

2

First Page

43

Last Page

44

ISSN

0354-950X

Disciplines

Medicine and Health Sciences

PubMedID

15771286

Department(s)

Department of Surgery

Document Type

Article

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