Gender differences in outcomes following endoscopic sinus surgery: a systematic review and meta-analysis.
Publication/Presentation Date
6-24-2024
Abstract
BACKGROUND: The extent to which gender affects outcomes in chronic rhinosinusitis (CRS) is unclear. The objective of this study was to examine differential outcomes between genders following endoscopic sinus surgery (ESS) among CRS patients.
METHODS: PubMed/Ovid, Embase and Cochrane databases were queried. Outcomes included disease burden on imaging and endoscopy, patient-reported outcome measures (PROMs) including the Sinonasal Outcome Test (SNOT-22), revision rates, and olfactory outcomes. Meta-analysis was performed using the Mantel-Haenszel method with random effects model.
RESULTS: Of 4,656 articles screened, 32 (n=103,499) were included for qualitative analysis and four (n=2,602) for meta-analysis. On qualitative analysis, 19 of the 32 studies noted a significant gender difference in post-operative outcomes, with five studies favoring women and 14 favoring men. Nine of 18 studies with PROMs noted a difference between genders, all favoring men. Olfactory outcomes were mixed with studies divided on favoring men vs women. No studies noted significant gender differences of disease burden on imaging or endoscopy. Across four studies included in the meta-analysis, women had higher preoperative and post-operative SNOT-22 scores.
CONCLUSION: Meta-analysis shows that women patients have worse pre and postoperative SNOT-22 scores. Postoperative gender differences are most apparent in studies that examined PROMs. Further research is needed to investigate the underlying causes and to mitigate disparities between genders.
ISSN
0300-0729
Published In/Presented At
Ryan, M. T., Patel, K., Fischer, J. L., Tolisano, A. M., McCoul, E. D., Lawlor, C., Parsel, S. M., & Riley, C. A. (2024). Gender differences in outcomes following endoscopic sinus surgery: a systematic review and meta-analysis. Rhinology, 10.4193/Rhin24.009. Advance online publication. https://doi.org/10.4193/Rhin24.009
Disciplines
Medicine and Health Sciences
PubMedID
38913328
Department(s)
Department of Surgery
Document Type
Article