Prevention of Iatrogenic Fluid Overload with Naloxone Infusions: A Patient Safety Initiative.
A higher number of patients admitted to hospital systems are requiring a naloxone infusion for treatment of opioid toxicity. While naloxone is a safe antidote for the treatment of opioid toxicity, this is not without the risk of iatrogenic harm. During standard pharmacy medication safety review process, it was identified that our standard naloxone concentration protocol would deliver four-times the standard maintenance fluid rate to our pediatric patient population. After this risk was identified, a multidisciplinary review process of our naloxone infusion protocol was performed to help mitigate the potential risk of fluid overload. Our updated naloxone infusion protocol will result in close to a 10-fold reduction in fluids required for our naloxone infusion protocol to better align with the American Society of Health-System Pharmacists' standardized for safety initiative and reduce the potential for iatrogenic harm.
Published In/Presented At
Kennedy, C. L., Hayn, L. N., Ebeling-Koning, N. E., & Beauchamp, G. A. (2024). Prevention of Iatrogenic Fluid Overload with Naloxone Infusions: A Patient Safety Initiative. Journal of the American Pharmacists Association : JAPhA, S1544-3191(24)00005-0. Advance online publication. https://doi.org/10.1016/j.japh.2024.01.005
Medicine and Health Sciences
Department of Emergency Medicine, Department of Emergency Medicine Faculty, Department of Emergency Medicine Residents, Toxicology Division, Department of Pharmacy, Fellows and Residents