Title

Immunosuppressive Drugs and Fetal Outcome.

Publication/Presentation Date

11-1-2014

Abstract

Successful pregnancies have been reported in all types of solid-organ transplant recipients on a variety of immunosuppressive regimens. Immunosuppression is essential to maintain the transplanted organ and maternal health, thus the safety of these medications continues to be studied. This article reviews information in the literature and data from the National Transplantation Pregnancy Registry (NTPR) in the United States related to immunosuppressive medication and pregnancy. Although most maintenance immunosuppressive regimens have not been shown to affect the outcome of posttransplant pregnancies, mycophenolic acid products are associated with an increased incidence of spontaneous abortion and an increase in the incidence and a specific pattern of birth defects. When counseling transplant recipients about the prospect and safety of pregnancy, the health of the mother, her graft, and the developing fetus must all be taken into account.

Volume

28

Issue

8

First Page

1174

Last Page

1187

ISSN

1532-1932

Disciplines

Obstetrics and Gynecology | Other Medical Specialties | Surgery

PubMedID

25175414

Department(s)

Department of Surgery, Department of Surgery Faculty

Document Type

Article