Immunosuppressive Drugs and Fetal Outcome.
Publication/Presentation Date
11-1-2014
Abstract
Successful pregnancies have been reported in all types of solid-organ transplant recipients on a variety of immunosuppressive regimens. Immunosuppression is essential to maintain the transplanted organ and maternal health, thus the safety of these medications continues to be studied. This article reviews information in the literature and data from the National Transplantation Pregnancy Registry (NTPR) in the United States related to immunosuppressive medication and pregnancy. Although most maintenance immunosuppressive regimens have not been shown to affect the outcome of posttransplant pregnancies, mycophenolic acid products are associated with an increased incidence of spontaneous abortion and an increase in the incidence and a specific pattern of birth defects. When counseling transplant recipients about the prospect and safety of pregnancy, the health of the mother, her graft, and the developing fetus must all be taken into account.
Volume
28
Issue
8
First Page
1174
Last Page
1187
ISSN
1532-1932
Published In/Presented At
Coscia, L. A., Constantinescu, S., Davison, J. M., Moritz, M. J., & Armenti, V. T. (2014). Immunosuppressive drugs and fetal outcome. Best Practice & Research. Clinical Obstetrics & Gynaecology, 28(8), 1174-1187. doi:10.1016/j.bpobgyn.2014.07.020
Disciplines
Obstetrics and Gynecology | Other Medical Specialties | Surgery
PubMedID
25175414
LVHN link
http://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=25175414&site=ehost-live&scope=site
Department(s)
Department of Surgery, Department of Surgery Faculty
Document Type
Article