Tumor-targeting peptide-PNA-peptide chimeras for imaging overexpressed oncogene mRNAs.

Authors

• X Tian
• M R Aruva
• H R Wolfe
• W Qin
• E R Sauter
• M L Thakur
• S A Waldman
• E Wickstrom

Publication/Presentation Date

1-1-2005

Abstract

We have optimized a method involving continuous solid phase synthesis of chelator-peptide-PNA-peptide probes in order to noninvasively image oncogene mRNAs overexpressed in tumors. The PNA (peptide nucleic acid) probes carry cyclized peptide ligand analogs specific for receptors overexpressed on malignant breast or colorectal cancer cells, and chelators to bind radioactive metal ions, or a fluorophore. In vivo scintigraphic imaging of MCF7 xenografts in immunocompromised mice indicated that CCND1 and MYC [99sTc] chelator-PNA-D (CSKC) probes concentrated in MCF7 cells up to 7 times more than the corresponding mismatch controls.

Volume

24

Issue

5-7

First Page

1085

Last Page

1091

ISSN

1525-7770

Published In/Presented At

Tian, X., Aruva, M. R., Wolfe, H. R., Qin, W., Sauter, E. R., Thakur, M. L., Waldman, S. A., & Wickstrom, E. (2005). Tumor-targeting peptide-PNA-peptide chimeras for imaging overexpressed oncogene mRNAs. Nucleosides, nucleotides & nucleic acids, 24(5-7), 1085–1091. https://doi.org/10.1081/ncn-200059177

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

16248097

Department(s)

Administration and Leadership

Document Type

Article