Systems-based discovery advances drug development.
Publication/Presentation Date
4-1-2013
Abstract
Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target-based activities of specific molecules in cell-free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target-based algorithms into comprehensive, systems-level approaches offering value-added strategies for optimized drug discovery.
Volume
93
Issue
4
First Page
285
Last Page
287
ISSN
1532-6535
Published In/Presented At
Waldman, S. A., & Terzic, A. (2013). Systems-based discovery advances drug development. Clinical pharmacology and therapeutics, 93(4), 285–287. https://doi.org/10.1038/clpt.2013.21
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23511779
Department(s)
Administration and Leadership
Document Type
Article