Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA - update 2018.

Authors

• Yair Lotan
• Trinity J Bivalacqua
• Tracy Downs
• William Huang
• Jeffrey Jones
• Ashish M Kamat
• Badrinath Konety
• Per-Uno Malmström
• James McKiernan
• Michael O'Donnell
• Sanjay Patel
• Kamal Pohar
• Matthew Resnick
• Alexander Sankin
• Angela Smith
• Gary Steinberg
• Edouard Trabulsi
• Michael Woods
• Siamak Daneshmand

Publication/Presentation Date

6-1-2019

Abstract

Blue light cystoscopy (BLC) with hexaminolevulinate (HAL) during transurethral resection of bladder cancer improves detection of non-muscle-invasive bladder cancer (NMIBC) and reduces recurrence rates. Flexible BLC was approved by the FDA in 2018 for use in the surveillance setting and was demonstrated to improve detection. Results of a phase III prospective multicentre study of blue light flexible cystoscopy (BLFC) in surveillance of intermediate-risk and high-risk NMIBC showed that 20.6% of malignancies were identified only by BLFC. Improved detection rates in the surveillance setting are anticipated to lead to improved clinical outcomes by reducing future recurrences and earlier identification of tumours that are unresponsive to therapy. Thus, BLFC has a role in surveillance cystoscopy, and determining which patients will benefit from BLFC and optimal and cost-effective ways of incorporating this technology into surveillance cystoscopy must be developed.

Volume

16

Issue

6

First Page

377

Last Page

386

ISSN

1759-4820

Published In/Presented At

Lotan, Y., Bivalacqua, T. J., Downs, T., Huang, W., Jones, J., Kamat, A. M., Konety, B., Malmström, P. U., McKiernan, J., O'Donnell, M., Patel, S., Pohar, K., Resnick, M., Sankin, A., Smith, A., Steinberg, G., Trabulsi, E., Woods, M., & Daneshmand, S. (2019). Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA - update 2018. Nature reviews. Urology, 16(6), 377–386. https://doi.org/10.1038/s41585-019-0184-4

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

31019310

Department(s)

Administration and Leadership

Document Type

Article