Investigating the neurological function and anti-inflammatory effects of resveratrol in small mammal spinal cord injury models: A systematic review and meta-analysis.
Publication/Presentation Date
1-1-2026
Abstract
BACKGROUND: Spinal cord injury (SCI) produces serious neurological and medical problems. Resveratrol (RES), a natural polyphenol, possesses anti-inflammatory and antioxidant characteristics and has revealed neuroprotective ability in central nervous system diseases. This study investigated the therapeutic potential of RES in rat, mouse, and rabbit SCI models.
METHODS: Articles were identified from Medline, Embase, Scopus, and Web of Science until April 25, 2025. Studies evaluating RES with SCI models were included. Main results were locomotor function, inflammation, oxidative stress, apoptosis, and neuronal survival. Random-effects meta-analysis showed standardized mean differences (SMDs) and their
RESULTS: Twenty-six studies were included. RES improved locomotor function (SMD = 3.41,
CONCLUSION: In preclinical SCI models, RES is a promising neuroprotective agent. This suggests that further research is warranted regarding the potential role of RES in SCI treatment.
Volume
17
First Page
498
Last Page
498
ISSN
2229-5097
Published In/Presented At
Peyrovinasab, A., Janmohamadi, M., Vazirizadeh-Mahabadi, M., Yarahmadi, M., Sarveazad, A., Vaccaro, A., Rahimi-Movaghar, V., & Yousefifard, M. (2026). Investigating the neurological function and anti-inflammatory effects of resveratrol in small mammal spinal cord injury models: A systematic review and meta-analysis. Surgical neurology international, 17, 498. https://doi.org/10.25259/SNI_815_2026
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42829558
Department(s)
Administration and Leadership
Document Type
Article