Mean Arterial Pressure Augmentation for Acute Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Neurological Recovery and Mortality.
Publication/Presentation Date
6-5-2026
Abstract
Study DesignSystematic review.ObjectivesMaintenance of mean arterial pressure (MAP) at 85-90 mmHg after traumatic spinal cord injury (SCI) is widely recommended, but supporting evidence is limited. We performed a systematic review and meta-analysis to evaluate whether MAP augmentation improves outcomes after SCI.MethodsPubMed, Embase, and CENTRAL were searched through January 2026. Random-effects meta-analyses were performed. Prespecified cohort-level analyses compared standard (≥65 mmHg) with augmented MAP targets (≥85 mmHg). Weighted linear meta-regression explored dose-response relationships between achieved MAP and primary outcomes.ResultsThirty-three studies comprising 3535 patients were included. Neurological improvement occurred in 31.4% and 37.6% of patients subjected to standard and augmented MAP, respectively (
First Page
21925682261458879
Last Page
21925682261458879
ISSN
2192-5682
Published In/Presented At
Kale, K. M., Patel, S., Nischal, S. A., Ceccon, L., Heller, J., Jallo, J., Harrop, J. S., & Prasad, S. K. (2026). Mean Arterial Pressure Augmentation for Acute Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Neurological Recovery and Mortality. Global spine journal, 21925682261458879. Advance online publication. https://doi.org/10.1177/21925682261458879
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42246985
Department(s)
Administration and Leadership
Document Type
Article