Inflammatory hydrocephalus.
Publication/Presentation Date
11-1-2021
Abstract
Reparative inflammation is an important protective response that eliminates foreign organisms, damaged cells, and physical irritants. However, inappropriately triggered or sustained inflammation can respectively initiate, propagate, or prolong disease. Post-hemorrhagic (PHH) and post-infectious hydrocephalus (PIH) are the most common forms of hydrocephalus worldwide. They are treated using neurosurgical cerebrospinal fluid (CSF) diversion techniques with high complication and failure rates. Despite their distinct etiologies, clinical studies in human patients have shown PHH and PIH share similar CSF cytokine and immune cell profiles. Here, in light of recent work in model systems, we discuss the concept of "inflammatory hydrocephalus" to emphasize potential shared mechanisms and potential therapeutic vulnerabilities of these disorders. We propose that this change of emphasis could shift our thinking of PHH and PIH from a framework of life-long neurosurgical disorders to that of preventable conditions amenable to immunomodulation.
Volume
37
Issue
11
First Page
3341
Last Page
3353
ISSN
1433-0350
Published In/Presented At
Robert, S. M., Reeves, B. C., Marlier, A., Duy, P. Q., DeSpenza, T., Kundishora, A., Kiziltug, E., Singh, A., Allington, G., Alper, S. L., & Kahle, K. T. (2021). Inflammatory hydrocephalus. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 37(11), 3341–3353. https://doi.org/10.1007/s00381-021-05255-z
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34164718
Department(s)
Administration and Leadership
Document Type
Article