Profiles of resting state functional connectivity in temporal lobe epilepsy associated with post-laser interstitial thermal therapy seizure outcomes and semiologies.

Authors

• Mashaal Syed
• Jingya Miao
• Anish Sathe
• Kichang Kang
• Arichena Manmatharayan
• Michael Kogan
• Caio M Matias
• Ashwini Sharan
• Mahdi Alizadeh

Publication/Presentation Date

1-1-2023

Abstract

INTRODUCTION: It is now understood that in focal epilepsy, impacted neural regions are not limited to the epileptogenic zone. As such, further investigation into the underlying functional connectivity (FC) patterns in those enduring Temporal Lobe Epilepsy (TLE) with Mesial Temporal Sclerosis (MTS) is imperative to understanding the intricacies of the disease.

METHODS: The rsfMRIs of 17 healthy participants, 10 left-sided TLE-MTS patients with a pre-operative history of focal impaired awareness seizures (FIA), and 13 left-sided TLE-MTS patients with a pre-operative history of focal aware seizures (FA) were compared to determine the existence of distinct FC patterns with respect to seizure types. Similarly, the rsfMRIs of the above-mentioned healthy participants, 16 left-sided TLE-MTS individuals who were seizure-free (SF) 12 months postoperatively, and 16 left-sided TLE-MTS persons without seizure freedom (nSF) were interrogated. The ROI-to-ROI connectivity analysis included a total of 175 regions of interest (ROIs) and accounted for both age and duration of epileptic activity. Significant correlations were determined via two-sample

RESULTS: Comparisons of FA and FIA groups depicted significant correlations between the contralateral anterior cingulate gyrus, subgenual region, and the contralateral cerebellum, lobule III (

SIGNIFICANCE: FC analysis proves to be a lucrative modality for exploring unique signatures with respect to seizure types and postoperative outcomes. By furthering our understanding of the differences between epileptic phenotypes, we can achieve improvement in future treatment modalities not limited to targeting advancements.

Volume

2

First Page

1201682

Last Page

1201682

ISSN

2813-1193

Published In/Presented At

Syed, M., Miao, J., Sathe, A., Kang, K., Manmatharayan, A., Kogan, M., Matias, C. M., Sharan, A., & Alizadeh, M. (2023). Profiles of resting state functional connectivity in temporal lobe epilepsy associated with post-laser interstitial thermal therapy seizure outcomes and semiologies. Frontiers in neuroimaging, 2, 1201682. https://doi.org/10.3389/fnimg.2023.1201682

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

38025313

Department(s)

Administration and Leadership

Document Type

Article