Hippocampal pathology in fatal non-missile human head injury.
Publication/Presentation Date
1-1-1992
Abstract
The hippocampus has been known to be involved in fatal non-missile human head injury, although detailed histopathology of this lesion has yet to be described. This report documents the frequency and distribution of hippocampal damage in a consecutive series of 112 fatal human non-missile head injuries. Damage to the hippocampus was noted in 94 cases (84%). Lesions always involved the CA1 subfield and were bilateral in 70 cases. Other subfields of the hippocampus were involved less frequently. Lesions were focal in the majority of cases (58%). Pathological evidence of high intracranial pressure was present in 86% of the cases. Hypoxic brain damage in other regions of the brain was present in 74% of cases. Thus, the hippocampus is frequently damaged in fatal non-missile human head injury. The pattern of this damage is similar to that observed in experimental head injury. Hypoxia and high intracranial pressure are likely to contribute to the occurrence of human traumatic hippocampal damage but other mechanisms, such as excitotoxicity, are likely to be operative.
Volume
83
Issue
5
First Page
530
Last Page
534
ISSN
0001-6322
Published In/Presented At
Kotapka, M. J., Graham, D. I., Adams, J. H., & Gennarelli, T. A. (1992). Hippocampal pathology in fatal non-missile human head injury. Acta neuropathologica, 83(5), 530–534. https://doi.org/10.1007/BF00310031
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
1621508
Department(s)
Administration and Leadership
Document Type
Article