Cerebral venous oxygen content as a measure of brain energy metabolism with increased intracranial pressure and hyperventilation.
Publication/Presentation Date
12-1-1990
Abstract
In order to test the hypothesis that the cerebral arteriovenous oxygen difference (AVDO2) and venous oxygen content (VO2) could be used to monitor brain energy metabolism in the setting of increased intracranial pressure (ICP). 12 cats were studied with 31P-magnetic resonance spectroscopy. six cats were subjected to intracranial hypertension by cisternal infusion of saline. Energy failure occurred at an average AVDO2 of 8.4 +/- 3.2 vol% (+/- standard deviation) (range 4.7 to 14.7 vol%). The VO2 at the point of metabolic failure averaged 1.45 +/- 0.6 vol% and extended over a narrower range (1.0 to 2.9 vol%). In an additional six cats, ICP was raised to the threshold of metabolic failure and hyperventilation was then instituted (pCO2 10 to 18 torr). Five of the six cats experienced a drop in VO2 with hyperventilation. In two of these animals, hyperventilation resulted in a VO2 of 1.1 vol% or less and in metabolic failure as evidenced by a fall in phosphocreatine. It is concluded that a VO2 of less than 2 vol% is correlated with brain ischemia and that the safety of hyperventilation in the setting of increased ICP can be monitored by the use of VO2.
Volume
73
Issue
6
First Page
927
Last Page
932
ISSN
0022-3085
Published In/Presented At
Sutton, L. N., McLaughlin, A. C., Dante, S., Kotapka, M., Sinwell, T., & Mills, E. (1990). Cerebral venous oxygen content as a measure of brain energy metabolism with increased intracranial pressure and hyperventilation. Journal of neurosurgery, 73(6), 927–932. https://doi.org/10.3171/jns.1990.73.6.0927
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2230975
Department(s)
Administration and Leadership
Document Type
Article