Hypoxia is important in the biology and aggression of human glial brain tumors.
Publication/Presentation Date
12-15-2004
Abstract
We investigated whether increasing levels of tissue hypoxia, measured by the binding of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] or by Eppendorf needle electrodes, were associated with tumor aggressiveness in patients with previously untreated glial brain tumors. We hypothesized that more extensive and severe hypoxia would be present in tumor cells from patients bearing more clinically aggressive tumors. Hypoxia was measured with the 2-nitroimidazole imaging agent EF5 in 18 patients with supratentorial glial neoplasms. In 12 patients, needle electrode measurements were made intraoperatively. Time to recurrence was used as an indicator of tumor aggression and was analyzed as a function of EF5 binding, electrode values and recursive partitioning analysis (RPA) classification. On the basis of EF5 binding, WHO grade 2 tumors were characterized by modest cellular hypoxia (pO2s approximately 10%) and grade 3 tumors by modest-to-moderate hypoxia (pO2s approximately 10%- 2.5%). Severe hypoxia (approximately 0.1% oxygen) was present in 5 of 12 grade 4 tumors. A correlation between more rapid tumor recurrence and hypoxia was demonstrated with EF5 binding, but this relationship was not predicted by Eppendorf measurements.
Volume
10
Issue
24
First Page
8177
Last Page
8184
ISSN
1078-0432
Published In/Presented At
Evans, S. M., Judy, K. D., Dunphy, I., Jenkins, W. T., Hwang, W. T., Nelson, P. T., Lustig, R. A., Jenkins, K., Magarelli, D. P., Hahn, S. M., Collins, R. A., Grady, M. S., & Koch, C. J. (2004). Hypoxia is important in the biology and aggression of human glial brain tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 10(24), 8177–8184. https://doi.org/10.1158/1078-0432.CCR-04-1081
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15623592
Department(s)
Administration and Leadership
Document Type
Article