Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion.
Publication/Presentation Date
12-1-2017
Abstract
Post-traumatic headache is the most common symptom of postconcussion syndrome and becomes a chronic neurological disorder in a substantial proportion of patients. This review provides a brief overview of the epidemiology of postconcussion headache, research models used to study this disorder, as well as the proposed mechanisms. An objective of this review is to enhance the understanding of how the endogenous cannabinoid system is essential for maintaining the balance of the CNS and regulating inflammation after injury, and in turn making the endocannabinoid system a potential modulator of the trigeminal response to concussion. The review describes the role of endocannabinoid modulation of pain and the potential for use of phytocannabinoids to treat pain, migraine and concussion.
Volume
2
Issue
4
First Page
49
Last Page
49
ISSN
2056-3299
Published In/Presented At
Elliott, M. B., Ward, S. J., Abood, M. E., Tuma, R. F., & Jallo, J. I. (2017). Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion. Concussion (London, England), 2(4), CNC49. https://doi.org/10.2217/cnc-2017-0010
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
30202590
Department(s)
Administration and Leadership
Document Type
Article