Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution.
Publication/Presentation Date
9-1-2010
Abstract
Tremendous insight into the molecular and genetic pathogenesis of cerebral cavernous malformations (CCMs) has been gained over the past 2 decades. This includes the identification of 3 distinct genes involved in familial CCMs. Still, a number of unanswered questions regarding the process from gene mutation to vascular malformation remain. It is becoming more evident that the disruption of interendothelial junctions and ensuing vascular hyperpermeability play a principal role. The purpose of this review is to summarize the current understanding of CCM genes, associated proteins, and functional pathways. Promising molecular and genetic therapies targeted at identified molecular aberrations are discussed as well.
Volume
29
Issue
3
First Page
4
Last Page
4
ISSN
1092-0684
Published In/Presented At
Yadla, S., Jabbour, P. M., Shenkar, R., Shi, C., Campbell, P. G., & Awad, I. A. (2010). Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution. Neurosurgical focus, 29(3), E4. https://doi.org/10.3171/2010.5.FOCUS10121
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
20809762
Department(s)
Administration and Leadership
Document Type
Article