Volumetric surveillance of brain aneurysms: Pitfalls of MRA.
Publication/Presentation Date
10-1-2023
Abstract
INTRODUCTION: Untreated brain aneurysms are usually surveilled with serial MR imaging and evaluated with 2D multiplanar measurements. The assessment of aneurysm growth may be more accurate with volumetric analysis. We evaluated the accuracy of a magnetic resonance angiography (MRA) segmentation pipeline for aneurysm volume measurement and surveillance.
METHODS: A pipeline to determine aneurysm volume was developed and tested on two aneurysm phantoms imaged with time-of flight (TOF) MRA and 3D rotational angiography (3DRA). The accuracy of the pipeline was then evaluated by reconstructing 10 aneurysms imaged with contrast enhanced-MRA (CE-MRA) and 3DRA. This calibrated and refined post-processing pipeline was subsequently used to analyse aneurysms from our prospectively acquired database. Volume changes above the threshold of error were considered true volume changes. The accuracy of these measurements was analysed.
RESULTS: TOF-MRA reconstructions were not as accurate as CE-MRA reconstructions. When compared to 3DRA, CE-MRA underestimated aneurysm volume by 7.8% and did not accurately register the presence of blebs. Eighteen aneurysms (13 saccular and 5 fusiform) were analysed with the optimized 3D volume reconstruction pipeline, with a mean follow-up time of 11 months. Artifact accounted for 10.2% error in volume measurements using serial CE-MRA. When this margin of error was used to assess aneurysms volume in serial imaging with CE-MRA, only two fusiform aneurysms changed in volume. The variations in volume of these two fusiform aneurysms were caused by intra-mural and intrasaccular thrombosis.
CONCLUSIONS: CE-MRA and TOF-MRA 3D volume reconstructions may not register minor morphological changes such as the appearance of blebs. CE-MRA underestimates volume by 7.8% compared to 3DRA. Serial CE-MRA volume measurements had a larger margin of error of approximately 10.2%. MRA-based volumetric measurements may not be appropriate for aneurysm surveillance.
Volume
29
Issue
5
First Page
532
Last Page
539
ISSN
2385-2011
Published In/Presented At
Raghuram, A., Patel, R., Varon, A., Sabotin, R., Sanchez, S., Derdeyn, C. P., Jabbour, P., Hasan, D. M., & Samaniego, E. A. (2023). Volumetric surveillance of brain aneurysms: Pitfalls of MRA. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 29(5), 532–539. https://doi.org/10.1177/15910199221100619
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
35549745
Department(s)
Administration and Leadership
Document Type
Article