Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke.
Publication/Presentation Date
12-1-2024
Abstract
BACKGROUND: Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occlusions (DMVO) are not well understood.
METHODS: This retrospective analysis involved 1282 acute ischemic stroke (AIS) patients who underwent MT in 37 centers across North America, Asia, and Europe from September 2017 to July 2023. Data on demographics, clinical presentation, treatment specifics, and outcomes were collected. The primary outcomes were functional outcomes at 90 days post-MT, measured by modified Rankin Scale (mRS) scores. Secondary outcomes included reperfusion rates, mortality, and hemorrhagic complications.
RESULTS: Of the patients, 223 (34%) were on anticoagulation therapy. Anticoagulated patients were older (median age 78 vs 74 years;
CONCLUSION: Anticoagulated patients undergoing MT for AIS due to DMVO did not show significant differences in 90-day mRS outcomes, reperfusion, or hemorrhage compared to non-anticoagulated patients after adjustment for covariates.
Volume
9
Issue
4
First Page
896
Last Page
906
ISSN
2396-9881
Published In/Presented At
Salim, H., Musmar, B., Adeeb, N., Yedavalli, V., Lakhani, D., Grewal, S. S., El Naamani, K., Henninger, N., Sundararajan, S. H., Kühn, A. L., Khalife, J., Ghozy, S., Scarcia, L., Tan, B. Y., Regenhardt, R. W., Heit, J. J., Cancelliere, N. M., Bernstock, J. D., Rouchaud, A., Fiehler, J., … MAD MT Investigators (2024). Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke. European stroke journal, 9(4), 896–906. https://doi.org/10.1177/23969873241249295
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
38726983
Department(s)
Administration and Leadership
Document Type
Article