Patient's Age Impact on Stroke Risk and Intracranial Aneurysm Occlusion: SCENT Flow Diverter Study-A Nonrandomized Clinical Trial on Large and Giant Aneurysms.

Authors

• Ajay K Wakhloo
• Paul Jenkins
• Philip M Meyers
• Alexander L Coon
• Peter T Kan
• Ajit S Puri
• Joost de Vries
• Giuseppe Lanzino
• Mark D Bain
• Koji C Ebersole
• Babu G Welch
• Aclan Dogan
• Pascal M Jabbour
• J Mocco
• Adnan H Siddiqui
• Aquilla S Turk
• Philipp Taussky
• Ricardo A Hanel

Publication/Presentation Date

6-1-2026

Abstract

BACKGROUND AND OBJECTIVES: The prospective single-arm nonrandomized SCENT (Surpass Intracranial Aneurysm Embolization System Pivotal) trial on flow diverter treatment of large and giant intracranial aneurysms (IA) was analyzed for patients' age and IA characteristics affecting stroke and occlusion rates over 5 years (Trial registration NCT01716117).

METHODS: Impact on major ipsilateral stroke and IA occlusion was studied by stratifying age as 65 years and younger vs older than 65. Kaplan-Meier estimates of time to both endpoints, stratified by age, were created. Univariate predictors of time-to-stroke were analyzed using univariable proportional hazards regression models. Limited bivariable modeling was also attempted.

RESULTS: Of 180 patients with large or giant IA enrolled, 119 were 65 years and younger, whereas 61 were older than 65 years. The 3-year risk of stroke for the older than 65 years group (19.7%) was more than double that of the 65 years and younger group (9.2%),

CONCLUSION: Age older than 65 was associated with an increased risk of stroke and predictive of incomplete healing and increased time to healing.

Volume

7

Issue

2

First Page

000222

Last Page

000222

ISSN

2834-4383

Published In/Presented At

Wakhloo, A., Jenkins, P., Meyers, P., Coon, A., Kan, P., Puri, A., de Vries, J., Lanzino, G., Bain, M., Ebersole, K., Welch, B., Dogan, A., Jabbour, P., Mocco, J., Siddiqui, A., Turk, A., Taussky, P., & Hanel, R. (2026). Patient's Age Impact on Stroke Risk and Intracranial Aneurysm Occlusion: SCENT Flow Diverter Study-A Nonrandomized Clinical Trial on Large and Giant Aneurysms.. LVHN Scholarly Works. Retrieved from https://scholarlyworks.lvhn.org/administration-leadership/11083

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

42007246

Department(s)

Administration and Leadership

Document Type

Article