Biochemical composition and histologic structure of the forearm interosseous membrane.
Publication/Presentation Date
5-1-2003
Abstract
PURPOSE: The purpose of this study was to determine the structure and composition of the forearm interosseous membrane (IOM).
METHODS: The IOM of 12 cadaver forearms was fixed in formalin. After fixation 5 individual IOM fiber bundles per arm were separated by dissection, excised, and processed with hematoxylin-eosin, trichrome, and Verhoff-vanGeison stains. Nine additional fresh forearms were dissected and 5 IOM fiber bundles per arm were analyzed using the hydroxyproline assay. Bundles were evaluated at ulnar, central, and radial locations.
RESULTS: Histologic analysis of the IOM bundles obtained from the 12 fixed forearms showed an abundance of collagen in the main bundle central location (84% +/- 7.8%). A progressive increase in collagen was noted from distal to proximal bundles (r =.72). The hydroxyproline assay of collagen content of the main IOM bundle's central location from the 9 additional fresh forearms was 99.3% +/- 16.5%. There was no difference between bundles or location (power = 0.25 and 0.46).
CONCLUSIONS: We found that the IOM possesses a large collagen content arranged in fibrillar structures surrounded by elastin. Collagen was abundant in the proximal bundles and decreased in the distal bundles.
Volume
28
Issue
3
First Page
503
Last Page
510
ISSN
0363-5023
Published In/Presented At
McGinley, J. C., Heller, J. E., Fertala, A., Gaughan, J. P., & Kozin, S. H. (2003). Biochemical composition and histologic structure of the forearm interosseous membrane. The Journal of hand surgery, 28(3), 503–510. https://doi.org/10.1053/jhsu.2003.50059
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
12772112
Department(s)
Administration and Leadership
Document Type
Article