Unexpected dementia following prophylactic cranial irradiation for small cell lung cancer: case report.
Publication/Presentation Date
10-1-2007
Abstract
OBJECT: Prophylactic cranial irradiation (PCI) is commonly offered to patients with limited stage primary small cell lung cancer following a complete response.
METHODS: We present the unique case of a 76-year-old woman treated with PCI with a dose of 30 Gy in 15 fractions, at 200 cGy per fraction who developed progressive dementia.
CONCLUSIONS: This is the first reported case of dementia from PCI at this low dose per fraction. Patients need to be counseled regarding the risks and benefits of treatment, including dementia with treatment and risk of sequelae from CNS metastasis without treatment. The authors review the data supporting PCI and the incidence of radiation associated dementia.
Volume
85
Issue
1
First Page
77
Last Page
79
ISSN
0167-594X
Published In/Presented At
D'Ambrosio, D. J., Cohen, R. B., Glass, J., Konski, A., Buyyounouski, M. K., & Feigenberg, S. J. (2007). Unexpected dementia following prophylactic cranial irradiation for small cell lung cancer: case report. Journal of neuro-oncology, 85(1), 77–79. https://doi.org/10.1007/s11060-007-9384-5
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
17447010
Department(s)
Administration and Leadership
Document Type
Article