The m
Publication/Presentation Date
7-1-2022
Abstract
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most frequently occurring subtype of lymphoma. Unfortunately, the fundamental processes underlying the pathogenesis of DLBCL remain little understood. N
METHODS: The mRNA and protein expression of Wilms tumor 1-associating protein (WTAP) were determined using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis in lymphoma cells lines. The effects of WTAP expression on human lymphoma cells lines were assessed using cell proliferation assays, colony formation assays, and CCK8 assays. The Gene Expression Profiling Interactive Analysis (GEPIA) database was used to screen candidate gene targets of WTAP. Finally, the regulatory mechanisms of WTAP in DLBCL were investigated using methylated RNA immunoprecipitation (MeRIP) assays.
RESULTS: This study investigated the precise function of WTAP in DLBCL formation. The results demonstrated that the levels of m
CONCLUSIONS: In conclusion, these findings demonstrated that WTAP promotes DLBCL development via modulation of m
Volume
10
Issue
14
First Page
779
Last Page
779
ISSN
2305-5839
Published In/Presented At
Guo, S., Zhao, C., Fang, L., Xu, W., Dalia, S., Glass, J., Shikama, N., & Zhang, Z. (2022). The m6A methyltransferase WTAP plays a key role in the development of diffuse large B-cell lymphoma via regulating the m6A modification of catenin beta 1. Annals of translational medicine, 10(14), 779. https://doi.org/10.21037/atm-22-3027
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
35965785
Department(s)
Administration and Leadership
Document Type
Article