Radiation-induced tumor after stereotactic radiosurgery for an arteriovenous malformation: case report.
Publication/Presentation Date
11-1-2007
Abstract
OBJECTIVE: To present a rare case of a radiation-induced malignancy after stereotactic radiosurgery.
CLINICAL PRESENTATION: A 34-year-old woman presented with headaches. Imaging studies demonstrated a 4.5-cm arteriovenous malformation located in the pineal region. She was treated with a two-isocenter plan to a total dose of 1500 cGy prescribed to the 70% isodose line. She was lost to follow-up and presented with a change in mental status, nausea, headaches, and a generalized seizure 9 years later. Magnetic resonance imaging scans demonstrated a large, heterogeneously enhancing mass partially in the treatment volume.
INTERVENTION: Surgical debulking demonstrated an infiltrating glial neoplasm consistent with a glioblastoma multiforme. There was no staining for epidermal growth factor receptor, whereas greater than 75% of nuclei stained positively with p53.
CONCLUSION: The risk of radiation-induced tumors is currently unknown but needs to be determined to assess the risk-benefit profile for each patient.
Volume
61
Issue
5
First Page
1099
Last Page
1099
ISSN
1524-4040
Published In/Presented At
Berman, E. L., Eade, T. N., Brown, D., Weaver, M., Glass, J., Zorman, G., & Feigenberg, S. J. (2007). Radiation-induced tumor after stereotactic radiosurgery for an arteriovenous malformation: case report. Neurosurgery, 61(5), E1099. https://doi.org/10.1227/01.neu.0000303207.92617.4e
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18091259
Department(s)
Administration and Leadership
Document Type
Article