Prognostic implications of epidermal and platelet-derived growth factor receptor alterations in 2 cohorts of IDH
Publication/Presentation Date
1-1-2021
Abstract
BACKGROUND: Glioblastoma remains a deadly brain cancer with dismal prognosis. Genetic alterations, including
METHODS: We compiled a comprehensive clinically annotated database of IDHwt GBM patients treated at the Ohio State University Wexner Medical Center for whom we had mutational data through a CLIA-certified genomic laboratory. We then added data that is publicly available from Memorial Sloan Kettering Cancer Center through cBioPortal. Each of the genetic alterations (mutations, deletions, and amplifications) served as a variable in univariate and multivariate Cox proportional hazard models.
RESULTS: A total of 175 IDHwt GBM patients with available
CONCLUSIONS: Our data provide further insight into the impact of genetic alterations on various clinical outcomes in IDHwt GBM in 2 cohorts of patients with detailed clinical information and inspire new therapeutic strategies for IDHwt GBM.
Volume
3
Issue
1
First Page
127
Last Page
127
ISSN
2632-2498
Published In/Presented At
Alnahhas, I., Rayi, A., Guillermo Prieto Eibl, M. D. P., Ong, S., Giglio, P., & Puduvalli, V. (2021). Prognostic implications of epidermal and platelet-derived growth factor receptor alterations in 2 cohorts of IDHwt glioblastoma. Neuro-oncology advances, 3(1), vdab127. https://doi.org/10.1093/noajnl/vdab127
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34667950
Department(s)
Administration and Leadership
Document Type
Article