Single-cell RNA sequencing suggests different progenitor lineages between
Publication/Presentation Date
1-1-2026
Abstract
INTRODUCTION: Single-cell RNA sequencing has elucidated the heterogeneity in cancer. Single-cell glioblastoma (GBM) analyses have also proposed the resemblance of GBM cells to radial glia and outer radial glia (oRG) supporting the hypothesis that remnants of developmental tissue get reactivated in cancer. A recent study isolated neural progenitor cells (NPCs) from developing fetal human brain (gestational week 17-19) and classified NPCs based on their expression of THY1 (CD90), CD24 and EGFR. Ventricular radial glia are THY1
METHODS: We aimed to apply the classification above to
RESULTS: In
CONCLUSION:
Volume
8
Issue
1
First Page
003
Last Page
003
ISSN
2632-2498
Published In/Presented At
Alnahhas, I., Kayne, A., Khan, M. M., & Shi, W. (2026). Single-cell RNA sequencing suggests different progenitor lineages between IDH mutant and IDHwt glioma. Neuro-oncology advances, 8(1), vdag003. https://doi.org/10.1093/noajnl/vdag003
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
41727340
Department(s)
Administration and Leadership
Document Type
Article