Gliosarcoma arising from an anaplastic ependymoma: a case report of a rare entity.
Publication/Presentation Date
4-1-2004
Abstract
We report the first case of a gliosarcoma arising from an anaplastic ependymoma and the second case of gliosarcoma arising from any type of ependymal neoplasm. The patient was a 48-year-old woman with a solid and cystic, peripherally enhancing, 7-cm right frontal mass lesion. Histologically, the lesion displayed characteristics of anaplastic ependymoma (grade III, World Health Organization scale). The tumor recurred despite multiple cycles of postoperative radiation and chemotherapy. After the fourth recurrence, the tumor displayed a biphasic pattern of differentiation. The first pattern was similar to the original anaplastic ependymoma, whereas there was a second new sarcomatous pattern resembling fibrosarcoma that was admixed with and overrunning the ependymal component. The spectrum of gliosarcoma is therefore expanded to include not only astrocytic and oligodendroglial components but ependymal components as well.
Volume
35
Issue
4
First Page
512
Last Page
516
ISSN
0046-8177
Published In/Presented At
Behling, E., Birbe, R., Veznadaroglu, E., Andrews, D. W., Flanders, A., & Kenyon, L. C. (2004). Gliosarcoma arising from an anaplastic ependymoma: a case report of a rare entity. Human pathology, 35(4), 512–516. https://doi.org/10.1016/j.humpath.2003.10.018
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15116335
Department(s)
Administration and Leadership
Document Type
Article