The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline.
Publication/Presentation Date
1-1-2010
Abstract
QUESTION: Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment?
TARGET POPULATION: These recommendations apply to adults with solid brain metastases who have not experienced a seizure due to their metastatic brain disease.
RECOMMENDATION: Level 3 For adults with brain metastases who have not experienced a seizure due to their metastatic brain disease, routine prophylactic use of anticonvulsants is not recommended. Only a single underpowered randomized controlled trial (RCT), which did not detect a difference in seizure occurrence, provides evidence for decision-making purposes.
Volume
96
Issue
1
First Page
97
Last Page
102
ISSN
1573-7373
Published In/Presented At
Mikkelsen, T., Paleologos, N. A., Robinson, P. D., Ammirati, M., Andrews, D. W., Asher, A. L., Burri, S. H., Cobbs, C. S., Gaspar, L. E., Kondziolka, D., Linskey, M. E., Loeffler, J. S., McDermott, M., Mehta, M. P., Olson, J. J., Patchell, R. A., Ryken, T. C., & Kalkanis, S. N. (2010). The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology, 96(1), 97–102. https://doi.org/10.1007/s11060-009-0056-5
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19957015
Department(s)
Administration and Leadership
Document Type
Article