Investigating the Relationship Between Estrogen Replacement Therapy and Postoperative Complications Following Single-Level Lumbar Fusion: A Propensity Matched Analysis.
Publication/Presentation Date
10-7-2026
Abstract
Study DesignRetrospective Cohort.ObjectivesThe objective of this study was to investigate the relationship between preoperative estrogen replacement therapy and postoperative complications following single level lumbar fusion.MethodsThe TriNetX Research Network was queried for menopausal patients aged ≥ 50 years who underwent single level lumbar fusion. Patients issued ERT within the 12-month preoperative period were separated from patients with no documented ERT use. Propensity score matching was performed 1:1 based upon demographic characteristics and medical comorbidities. Rates of medical complications were assessed within 90 days postoperatively. Secondary outcomes include pseudarthrosis and revision surgery, which were evaluated within one and two years postoperatively. P < 0.05 indicates statistical significance.ResultsA total of 1,570 matched pairs were included. The incidence of PE was more than doubled in the ERT-positive cohort (RR 2.167, 95% CI 1.097 - 4.279,
First Page
21925682261494600
Last Page
21925682261494600
ISSN
2192-5682
Published In/Presented At
Stump, K. B., Giakas, A. M., Baek, G., Ng, M. K., Alvarez, A. P., Hilibrand, A. S., Vaccaro, A. R., Schroeder, G. D., & Kepler, C. K. (2026). Investigating the Relationship Between Estrogen Replacement Therapy and Postoperative Complications Following Single-Level Lumbar Fusion: A Propensity Matched Analysis. Global spine journal, 21925682261494600. Advance online publication. https://doi.org/10.1177/21925682261494600
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42842476
Department(s)
Administration and Leadership
Document Type
Article