Complete Versus Incomplete Surgical Resection in Intramedullary Ependymomas: A Systematic Review and Meta-analysis.

Publication/Presentation Date

6-1-2021

Abstract

STUDY DESIGN: Systematic review.

OBJECTIVE: To compare outcomes of complete versus incomplete resection in primary intramedullary spinal cord ependymoma.

METHODS: A comprehensive search of the MEDLINE, CENTRAL, and Embase databases was conducted by 2 independent investigators. Random-effect meta-analysis and meta-regression with seven covariates were performed to evaluate the reason for the heterogeneity among studies. We also used individual patient data in the integrative analysis to compare complete and incomplete resection based on 4 outcomes: progression-free survival (PFS), overall survival (OS), postoperative neurological improvement (PNI), and follow-up neurological improvement (FNI).

RESULTS: A total of 23 studies were identified, including 407 cases. Significant heterogeneity among included studies was observed in risk estimates (I

CONCLUSION: The data presented in this study showed that OS was not significantly affected by the degree of surgery. However, complete resection of intramedullary ependymomas provides the optimal outcomes with longer PFS and better long-term neurological outcomes than incomplete resection.

Volume

11

Issue

5

First Page

761

Last Page

773

ISSN

2192-5682

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

32783515

Department(s)

Administration and Leadership

Document Type

Article

Link to Full Text

Share

COinS