Design and challenges of a randomized clinical trial of medical expulsive therapy (tamsulosin) for urolithiasis in the emergency department.
Publication/Presentation Date
1-1-2017
Abstract
Urolithiasis or urinary stone disease has been estimated to affect about 1 in 11 Americans. Patients with urinary stone disease commonly present to the emergency department for management of their acute pain. In addition to providing analgesia, administration of drug (medical expulsive therapy) is often prescribed to assist passage of the urinary stone. In this methodology paper, we describe the design of a prospective, multi-center, randomized, double-blind placebo controlled clinical trial of the alpha-adrenergic blocker, tamsulosin, to evaluate its effectiveness as medical expulsive therapy. In addition, we describe the unique challenges of conducting a trial of this type within the setting of the emergency department.
Volume
52
First Page
91
Last Page
94
ISSN
1559-2030
Published In/Presented At
Burrows, P. K., Hollander, J. E., Wolfson, A. B., Kurz, M. C., Richards, L., DiFiore, S., Watts, P., Patkar, N., Brown, J., Jackman, S., Kirkali, Z., Kusek, J. W., Michel, C., Meltzer, A. C., & STONE Study Investigators (2017). Design and challenges of a randomized clinical trial of medical expulsive therapy (tamsulosin) for urolithiasis in the emergency department. Contemporary clinical trials, 52, 91–94. https://doi.org/10.1016/j.cct.2016.11.010
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
27890522
Department(s)
Administration and Leadership
Document Type
Article