Antitumor activity of a human cytotoxic T-cell line (TALL-104) in brain tumor xenografts.

Authors

• B Geoerger
• C B Tang
• A Cesano
• S Visonneau
• S Marwaha
• K D Judy
• L N Sutton
• D Santoli
• P C Phillips

Publication/Presentation Date

4-1-2000

Abstract

Malignant glioma in adults and primitive neuroectodermal tumors/medulloblastomas in children are the most common malignant primary brain tumors that either respond poorly to current treatment or tend to recur. Adoptive therapy with TALL-104 cells-an IL-2-dependent, major histocompatibility complex nonrestricted, cytotoxic T-cell line-has demonstrated significant antitumor activity against a broad range of implanted or spontaneously arising tumors. This study investigates distribution of systemically and locally administered TALL-104 cells and their efficacy in effecting survival of a rat model of human brain tumor. In vitro, TALL-104 cells showed significant cytotoxic activity when added to human glioblastoma cell lines U-87 MG, U-251 MG, and A1690; the medulloblastoma cell lines DAOY, D283 Med, and D341 Med; and the epidermoid cancer cell line A431. In brain tumor-bearing rats, the amount of fluorescent dye-labeled TALL-104 cells in brain increased after they were given by intracarotid injection as compared with i.v. cell administration. However, TALL-104 cells rapidly decreased to low levels within 1 h after intracarotid injection. This finding suggests that TALL-104 cells given systemically may not invade brain or tumor tissues, but rather may remain in the vascular system, making this approach less efficient for brain tumor treatment. In a model of athymic rats engrafted with human A431 carcinoma brain tumor, repetitive local administration of TALL-104 cells directly into the tumor bed resulted in a significant increase in survival time compared with control animals. Therefore, local therapy with TALL-104 cells may be a novel and highly effective treatment approach for malignant brain tumors.

Volume

2

Issue

2

First Page

103

Last Page

113

ISSN

1522-8517

Published In/Presented At

Geoerger, B., Tang, C. B., Cesano, A., Visonneau, S., Marwaha, S., Judy, K. D., Sutton, L. N., Santoli, D., & Phillips, P. C. (2000). Antitumor activity of a human cytotoxic T-cell line (TALL-104) in brain tumor xenografts. Neuro-oncology, 2(2), 103–113. https://doi.org/10.1093/neuonc/2.2.103

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

11303619

Department(s)

Administration and Leadership

Document Type

Article