Early gene changes in myocardial ischemia.
Publication/Presentation Date
10-1-1994
Abstract
After certain periods of myocardial ischemia and reperfusion, cardiac dysfunction exists in the absence of myonecrosis. In a blood-perfused isolated rat heart model, we have demonstrated early gene changes that are associated with global myocardial "stunning." Early gene changes included elevations in the expression of messenger RNAs for HSP70, c-myc and c-fos. Increased expression of messenger RNAs for protooncogenes is an important observation because of the role of protooncogenes as nuclear transcription factors. From these study findings, it would appear that the stunning state is associated with early gene changes that may signal the induction of a hypertrophic process. Subsequent studies are required to demonstrate the exact events which take place in the course of stunning that directly initiate an alteration in gene expression.
Volume
58
Issue
4
First Page
1282
Last Page
1284
ISSN
0003-4975
Published In/Presented At
Wechsler, A. S., Entwistle, J. C., 3rd, Yeh, T., Jr, Ding, M., & Jakoi, E. R. (1994). Early gene changes in myocardial ischemia. The Annals of thoracic surgery, 58(4), 1282–1284. https://doi.org/10.1016/0003-4975(94)90529-0
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
7944806
Department(s)
Administration and Leadership
Document Type
Article